New glycosides from Tetracentron sinense and their cytotoxic activity

作者：Wang Yi Fen; Lai Gou Fang; Efferth Thomas^*; Cao Jian Xin; Luo Shi De

来源：Chemistry and Biodiversity, 2006, 3(9): 1023-1030.

DOI：10.1002/cbdv.200690100

One novel neolignan (tetracentronsine; 1), one new indole alkaloid (= 3-(2-hydroxyethyl)-1H-indole-5-O-beta-D-glucopyranoside; 2), and two new phenol derivatives, 3-{2-[(beta-glucopyranosyl)oxy]-4,5(methylenedioxy)phenyl}propanoic acid (3) and methyl 3-{2-[(beta-glucopyranosyl)oxy]-4,5-(methylenedioxy)phenyl}propanoate (4), together with six known compounds were isolated from the stem bark of Tetracentron sinense. Their structures were determined by spectral analysis, including 1D- and 2D-NMR, and MS analyses. These compounds were tested for their cytotoxic activity against human leukaemia cells in vitro. Among them, compound 2, (E)-3-(4-hydroxyphenyl)-N-[2-(4-hydroxyphenyl)ethyl]prop-2-enamide (5), and maslinic acid (6) showed significant inhibitory activities against human leukaemia cells CCRF-CEM and its multi drug-resistant sub-line, CEM/ADR5000, with IC50, values in a range of 7.1 to 29.7 mu m.

• 出版日期2006
• 单位中国科学院昆明植物研究所