科研之友
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摘要
Background: Depression and weight change are linked, but there is a paucity of studies on their association during clinical treatment. The present study investigated how risk factors for a weight gain of at least 10% (major weight gain) and mental health modify their mutual association during a 6-year prospective follow-up of depressed outpatients. %26lt;br%26gt;Method: The study sample consisted of 121 depressed treatment-seeking outpatients with a mean age of 44.9 years. A 6-year follow-up started in January 1996. At baseline and on follow-up after 2 and 6 years, psychiatric diagnoses were obtained using the Structured Clinical Interview for DSM-III-R (SCID-I), while cluster C personality disorders (PD) were assessed on 6-month follow-up (SCID-II). Depression was also assessed with the Hamilton Rating Scale for Depression (HAM-D) and general psychopathology with the Symptom Checklist-90 (SCL-90) at baseline and at the end of the 6-year follow-up. Weight changes were based on measurements at baseline and at the end of the follow-up. Logistic regression was used to study the factors associated with major weight gain (%26gt;= 10%). %26lt;br%26gt;Results: Altogether, 16% of the study sample experienced major weight gain during the 6-year follow-up. Adverse childhood/adolescent experiences as a self-perceived cause of depression (OR 3.72, 95% CI 1.06-13.1, p = 0.040), higher scores in the HAM-D (OR 1.11, 95% CI 1.02-1.22, p = 0.019) and the SCL-90 subscale of anxiety (OR 2.22, 95% CI 1.11-4.42, p = 0.023) at baseline, and cluster C PD at 6 months (OR 3.16, 95% CI 1.11-8.97, p = 0.031) were separately associated with major weight gain after adjusting for age, gender, and baseline body mass index (BMI). %26lt;br%26gt;Conclusion: The severity of depressive and anxiety symptoms and linking adverse childhood with depression at the beginning of treatment, as well as cluster C PD at 6 months, were predictors of major weight gain.
- 出版日期2013-8
