Analgesic and Anti-inflammatory Activity of Teucrium chamaedrys Leaves Aqueous Extract in Male Rats

作者：Pourmotabbed Ali; Farshchi Amir^*; Ghiasi Golbarg; Khatabi Peyman Malek

来源：Iranian Journal of Basic Medical Sciences, 2010, 13(3): 119-125.

• Analgesic
• Anti-inflammatory
• Formalin test
• Tail flick
• Teucrium chamaedrys

Objective(s)
Current study was undertaken to investigate the analgesic and anti-inflammatory effects of the aqueous extract of Teucrium chamaedrys in mice and rats.
Materials and Methods
For evaluating of analgesic and anti-inflammatory activity, we used the carrageenan- and dextran-induced paw oedema, acetic acid-induced writhing, tail flick and formalin pain tests.
Results
The extract of T chamaedrys (50-200 mg/kg) and acetylsalicylic acid (100 mg/kg) produced a significant (P< 0.01) inhibition of the second phase response in the formalin pain model, while only the high dose (200 mg/kg) of the extract showed an analgesic effect in the first phase. The extract also inhibited acetic acid-induced abdominal writhes in a dose-dependent manner. The tail flick latency was dose dependently enhanced by the extract but this was significantly (P< 0.05) lower than that produced by morphine (10 mg/kg). The extract (25-250 mg/kg) administered 1 hr before carrageenan-induced paw swelling produced a dose dependent inhibition of the oedema. No effect was observed with the dextran-induced oedema model. Results of the phytochemical screening show the presence of alkaloids, flavonoids and triterpenoids in the extract.
Conclusion
The data obtained also suggest that the anti-inflammatory and analgesic effects of the extract may be mediated via both peripheral and central mechanisms. The role of alkaloids, flavonoids and triterpenoids will evaluate in future studies.

• 出版日期2010