Efficient One-Pot Synthesis of Novel Spirooxindole-Fused Phosphorous Heterocycle Derivatives by a Three-Component Domino Reaction

作者：Liu, Rendie; Wu, Mingshu^*; Li, Guozhu

来源：Heteroatom Chemistry, 2014, 25(3): 140-146.

DOI：10.1002/hc.21146

• ALPHA-AMINOPHOSPHONIC ACIDS
• MULTICOMPONENT REACTIONS
• STEREOSELECTIVE-SYNTHESIS
• CHEMISTRY
• OXINDOLES

Alkyl vinyl selenides react with diverse secondary phosphines and elemental selenium in a 1.1:1:2 molar ratio (120-124 degrees C, 20-40 min, 1,4-dioxane) to afford selectively earlier unknown diselenophosphinic Se-esters, R2P(Se)SeCH(Me)SeR ', in 82-99% yield. This three-component atom-economic reaction proceeds via intermediate formation of diselenophosphinic acid R2P(Se)SeH (generated from secondary phosphine and selenium), which adds to the double bond of vinyl selenide in a Markovnikov manner to give the target products.

• 出版日期2014-5
• 单位海南师范大学