MUC1 (CD227): a multi-tasked molecule

作者：Apostolopoulos Vasso^*; Stojanovska Lily; Gargosky Sharron E

来源：Cellular and Molecular Life Sciences, 2015, 72(23): 4475-4500.

DOI：10.1007/s00018-015-2014-z

• MUC1
• CD227
• PEM
• EMA
• MUC1 isoforms
• MUC1 expression
• MUC1 structure
• MUC1 and disease
• MUC1 and pathogens
• MUC1 and cancer

Mucin 1 (MUC1 [CD227]) is a high-molecular weight (> 400 kDa), type I membrane-tethered glycoprotein that is expressed on epithelial cells and extends far above the glycocalyx. MUC1 is overexpressed and aberrantly glycosylated in adenocarcinomas and in hematological malignancies. As a result, MUC1 has been a target for tumor immunotherapeutic studies in mice and in humans. MUC1 has been shown to have anti-adhesive and immunosuppressive properties, protects against infections, and is involved in the oncogenic process as well as in cell signaling. In addition, MUC1 plays a key role in the reproductive tract, in the immune system (affecting dendritic cells, monocytes, T cells, and B cells), and in chronic inflammatory diseases. Evidence for all of these roles for MUC1 is discussed herein and demonstrates that MUC1 is truly a multitasked molecule.

• 出版日期2015-12