Potent inhibitors of Huntingtin protein aggregation in a cell-based assay

作者：Rinderspacher Alison; Cremona Maria Laura; Liu Yidong; Deng Shi Xian; Gong Gangli; Aulner Nathalie; Toebben Udo; Myers Katherine; Chung Caty; Andersen Monique; Vidovic Dusica; Schuerer Stephan; Branden Lars; Yamamoto Ai; Landry Donald W^*

来源：Bioorganic & Medicinal Chemistry Letters, 2009, 19(6): 1715-1717.

DOI：10.1016/j.bmcl.2009.01.087

• Huntington's disease
• Huntingtin protein
• Polyglutamine aggregates
• Inhibitors of huntingtin protein aggregation
• High-throughput screen
• Quinazoline

A quinazoline that decreases polyglutamine aggregate burden in a cell-based assay was identified from a high-throughput screen of a chemical-compound library, provided by the NIH Molecular Libraries Small Molecule Repository (MLSMR). A structure and activity study yielded leads with submicromolar potency.

• 出版日期2009-3-15