Antinociceptive and anti-inflammatory activities of iridoid glycosides extract of Lamiophlomis rotata (Benth.) Kudo

作者：Li, Maoxing; Shang, Xiaofei; Zang, Ruxue; Jia, Zhengping^*; Fan, Pengcheng; Ying, Qiang; Wei, Lili

来源：Fitoterapia, 2010, 81(3): 167-172.

DOI：10.1016/j.fitote.2009.08.018

• Lamiophlomis rotata
• Iridoid glycoside
• Antinociceptive activity
• Anti-inflammatory activity

Lamtophlomis rotata (Benth ) Kudo is a perennial herb (Labiatae) used as the Tibetan traditional medicine with the effects of alleviating pain, detumescence, hemostasis, promoting blood circulation to remove blood stasis and reinforcing marrow In this study, we investigated the antinociceptive and anti-inflammatory activities of iridoid glycosides extract of L. rotata (IGLR) in mice Our results showed that the iridoid glycosides extract could decrease acetic-acid-induced writhings times and formalin-induced lickings times. Inhibit carrageenam-induced hind paw edema and xylene-induced ear swelling, and suppress peritoneal capillary permeability and leukocyte infiltration also induced by ace

• 出版日期2010-4
• 单位兰州大学; 中国人民解放军兰州军区兰州总医院