An electrochemiluminescence biosensor for Kras mutations based on locked nucleic acid functionalized DNA walkers and hyperbranched rolling circle amplification

作者：Zhang, Ying; Wang, Lixu; Luo, Fang^*; Qiu, Bin; Guo, Longhua; Weng, Zuquan^*; Lina, Zhenyu; Chen, Guonan

来源：Chemical Communications, 2017, 53(20): 2910-2913.

DOI：10.1039/c7cc00009j

• ELECTROCHEMICAL BIOSENSOR
• COLORECTAL-CANCER
• ASSAY
• DISCRIMINATION
• CETUXIMAB
• PROTEINS
• RELEASE
• PCR

Herein, an electrochemiluminescence (ECL) biosensor for ultrasensitive and specific detection of Kras mutant genes has been developed on the basis of the high discrimination capability of locked nucleic acid (LNA) and dual signal amplification techniques including DNA walkers and hyperbranched rolling circle amplification (HRCA).

• 出版日期2017-3-11
• 单位福州大学