Low nitric oxide bioavailability is associated with better responses to sildenafil in patients with erectile dysfunction

作者：Muniz Jaqueline J; Lacchini Riccardo; Sertorio Jonas T C; Jordao Alceu A Jr; Nobre Yuri T D A; Tucci Silvio Jr; Martins Antonio C P; Tanus Santos Jose E^*

来源：Naunyn-Schmiedeberg's Archives of Pharmacology, 2013, 386(9): 805-811.

DOI：10.1007/s00210-013-0882-z

• Erectile dysfunction
• Nitric oxide
• Nitrite
• Oxidative stress
• Sildenafil

Erectile dysED) is a multifactorial disease associated with vascular dysfunction, low nitric oxide (NO) bioavailability, and oxidative stress. However, it is not known whether low NO bioavailability and oxidative stress affect the responsiveness of ED patients to sildenafil. We tested this hypothesis by studying 28 healthy subjects (control group), 26 patients with ED without comorbidities (ED group), and 18 patients with ED and diabetes mellitus (ED/DM group). The International Index for Erectile IIEF) questionnaire was used to assess the erectile function of all participants, and their responsiveness to sildenafil was assessed as the percentage of change in the five-item version of IIEF score before and after sildenafil treatment. Levels of whole blood nitrite, antioxidants markers (ferric reducing ability of plasma (FRAP) and reduced glutathione), and oxidative stress markers (thiobarbituric acid reactive substance and protein carbonyl) were determined. We found a negative correlation between whole blood nitrite levels and the responses to sildenafil in both ED groups (P < 0.05). FRAP correlated negatively with the responses to sildenafil in the ED/DM group (P < 0.05). No other significant associations were found. Our findings show evidence that low NO bioavailability is associated with better responses to sildenafil in patients with ED (with or without DM).

• 出版日期2013-9