Acetamiprid Residues in Male Mice and its Effect on Liver Function

作者：Yi Wang; Zhang Jiao Jiao; Xiang Hai Yang; Jia Hua; Zhang; Wang Xian Zhong^*

来源：Journal of Animal and Veterinary Advances, 2012, 11(15): 2706-2710.

• Acetamiprid
• mice
• liver
• residues
• liver function
• impairment

This study was performed to identify whether acetamiprid could residue in liver and kidney and its effects on liver function. Fifty adult Kunming male mice weighting 25-30 g were randomly grouped and ten mice in each group (five groups: control, blank, acetamiprid alone, acetamiprid+vitamin E, vitamin E alone); all groups were administered for 35 days by intragastric gavage. The residue in the tissues had been detected by the Liquid Chromatography coupled with tandem Mass Spectrometry (LC-MS/MS) and the serum biochemistry parameters were analyzed by an automatic chemistry analyzer. Acetamiprid induced a wide range of nervous signs in mice; the concentration of acetamiprid in liver was higher than that of kidney p < 0.05. Furthermore, acetamiprid increased the activity of Alanine Transaminase (ALT), Aspartate Aminotransferase (AST), Alkaline Phosphatase (ALP) (p < 0.05 for all) but reduced the activity of Total Protein (TP) and Albumin (ALB) (p < 0.05, for both). However, Vitamin E ameliorated the effects of acetamiprid on these parameters, compared to the acetamiprid only group (p < 0.05). The results indicated that the liver was the main organ of acetamiprid residues and acemiprid could affect liver function but VE could reduce acetamiprid-induced impairment.

• 出版日期2012
• 单位西南大学