Antiangiogenic Polyketides from Peperomia dindygulensis Miq.

作者：Wang, Qi-Wei; Yu, De-Hong; Lin, Meng-Gan; Zhao, Mei; Zhu, Wen-Jun; Lu, Qin; Li, Gui-Xiu; Wang, Chao; Yang, Yi-Fang; Qin, Xue-Mei; Fang, Chao^*; Chen, Hong-Zhuan; Yang, Guo-Hong

来源：Molecules, 2012, 17(4): 4474-4483.

DOI：10.3390/molecules17044474

• Peperomia dindygulensis Miq.
• polyketides
• antiangiogenic activity

Two new polyketides: 2Z-(heptadec-12-enyl)-4-hydroxy-3,4,7,8-tetrahydro-2H-chromen-5(6H)-one (1) and 2-(heptadec-12-enyl)-5-hydroxy-5,6,7,8-tetrahydrochromen-4-one (2), together with eleven known compounds: 4-hydroxy-2-[(3,4-methylenedioxy-phenyl)tridecanoyl] cyclohexane-1,3-dione (3), oleiferinone (4), 4-hydroxy-2-[(3,4-methylenedioxy-phenyl)undecanoyl] cyclohexane-1,3-dione (5), 4-hydroxy-2-[(11-phenylundecanoyl)cyclohexane-1,3-dione (6), proctorione C (7), surinone C (8), 5-hydroxy-7,8,4'-trimethoxyflavone (9), 5-hydroxy-7,8,3',4'-tetramethoxyflavone (10), 5-hydroxy-7,3',4'-trimethoxyflavone (11), 5,8-dihydroxy-7,3',4'-trimethoxyflavone (12) and cepharanone B (13) were isolated from the whole plant of Peperomia dindygulensis Miq. Their structures were elucidated by spectroscopic methods, including 2D-NMR techniques. Compounds 2, 3, 5 and 8 inhibited human umbilical vein endothelial cell (HUVEC) proliferation and compounds 5 and 8 sharply suppressed HUVEC tube formation.

• 出版日期2012-4
• 单位山西大学; 上海医药工业研究院; 河北医科大学; 上海交通大学