Antibiotic Resistance as a Stress Response: Recovery of High-Level Oxacillin Resistance in Methicillin-Resistant Staphylococcus aureus "Auxiliary" (fem) Mutants by Induction of the Stringent Stress Response

作者：Kim Choon Keun; Milheirico Catarina; de Lencastre Herminia; Tomasz Alexander^*

来源：Antimicrobial Agents and Chemotherapy, 2017, 61(8): e00313-17.

DOI：10.1128/AAC.00313-17

• stress response
• auxiliary genes
• oxacillin resistance expression

Studies with methicillin-resistant Staphylococcus aureus (MRSA) strain COL have shown that the optimal resistance phenotype requires not only mecA but also a large number of "auxiliary genes" identified by Tn551 mutagenesis. The majority of auxiliary mutants showed greatly increased levels of oxacillin resistance when grown in the presence of sub-MICs of mupirocin, suggesting that the mechanism of reduced resistance in the auxiliary mutants involved the interruption of a stringent stress response, causing reduced production of penicillin-binding protein 2A (PBP 2A).

• 出版日期2017-8