Genetic Variation: Impact on Folate (and Choline) Bioefficacy

作者：West Allyson A; Caudill Marie A^*

来源：International Journal for Vitamin and Nutrition Research, 2010, 80(4-5): 319-329.

DOI：10.1024/0300-9831/a000040

• genetic variation
• MTHFR
• homocysteine
• folate
• choline
• serum folate
• folate bioefficacy
• folate bioavailability
• dietary recommendations
• folate RDA

Folate and choline are water-soluble micronutrients that serve as methyl donors in the conversion of homocysteine to methionine. Inadequacy of these nutrients can disturb one-carbon metabolism as evidenced by alterations in circulating folate and/or plasma homocysteine. Among common genetic variants that reside in genes regulating folate absorptive and metabolic processes, homozygosity for the MTHFR 677C>T variant has consistently been shown to have robust effects on status markers. This paper will review the impact of genetic variants in folate-metabolizing genes on folate and choline bioefficacy. Nutrient-gene and gene-gene interactions will be considered along with the need to account for these genetic variants when updating dietary folate and choline recommendations.

• 出版日期2010-10