Highly Enantioselective Total Synthesis of (-)-(3 ' S)-Lomatin and ( )-(3 ' S,4 ' R)-trans-Khellactone

作者：Page Philip C Bulman^*; Appleby Louise F; Day David; Chan Yohan; Buckley Benjamin R; Allin Steven M; McKenzie Michael J

来源：Organic Letters, 2009, 11(9): 1991-1993.

DOI：10.1021/ol900444h

Concise highly enantioselective three-step syntheses are described for (-)-(3'S)-lomatin and (+)-(3'S,4'R)-trans-khellactone from 7-hydroxycoumarin in 97% ee and in 57% and 58% overall yields, respectively, using nonaqueous enantioselective epoxidation by an iminium salt as the key step.

• 出版日期2009-5-7