DEFB1 gene 5%26apos; untranslated region ( UTR) polymorphisms are marginally involved in inflammatory bowel disease in south Brazilians

作者：Wilson T J; Jobim M^*; Segat L; Bianco A M; Salim P H; Portela P; Jobim L F; Damin D C; Schwartsmann G; Roesler R; Crovella S

来源：International Journal of Immunogenetics, 2014, 41(2): 138-142.

DOI：10.1111/iji.12089

The possible association of three DEFB1 gene polymorphisms with susceptibility to develop ulcerative colitis (UC) and Crohn%26apos;s disease (CD) was investigated in Brazilian patients and controls. Although a clear and strong association between functional 5-UTR DEFB1 SNPs and susceptibility/protection to IBDs cannot be drawn, our results suggest a possible involvement of DEFB1 gene in inflammatory bowel diseases, especially with the colonic localization of Crohn%26apos;s disease.

• 出版日期2014-4