MicroRNAs: powerful new regulators of heart disease and provocative therapeutic targets

作者:Van Rooij Eva; Olson Eric N*
来源:Journal of Clinical Investigation, 2007, 117(9): 2369-2376.
DOI:10.1172/JC133099

摘要

MicroRNAs act as negative regulators of gene expression by inhibiting the translation or promoting the degradation of target mRNAs. Recent studies have revealed key roles of microRNAs as regulators of the growth, development, function, and stress responsiveness of the heart, providing glimpses of undiscovered regulatory mechanisms and potential therapeutic targets for the treatment of heart disease.

  • 出版日期2007-9

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