Actinobacillus succinogenes: Advances on succinic acid production and prospects for development of integrated biorefineries

作者：Pateraki Chrysanthi; Patsalou Maria; Vlysidis Anestis; Kopsahelis Nikolaos; Webb Colin; Koutinas Apostolis A^*; Koutinas Michalis^*

来源：Biochemical Engineering Journal, 2016, 112: 285-303.

DOI：10.1016/j.bej.2016.04.005

• Actinobacillus succinogenes
• Bioconversion
• Product inhibition
• Downstream processing
• Integrated biorefineries
• Renewable resources

Actinobacillus succinogenes is a wild-type bacterial strain, isolated from bovine rumen, known as one of the most efficient natural producers of succinic acid. Herein, the factors contributing to the fermentative production of succinic acid by A. succinogenes are reviewed with particular focus on raw materials, culture conditions, significance of carbon dioxide availability and downstream separation and purification. The metabolic potential of this strain is evaluated through discussion of the pathways involved in succinic acid production, genome analysis as well as the development of A. succinogenes mutants. The review also addresses the importance of by-product formation during fermentation that constitutes an important aspect regulating succinic acid production by A. succinogenes. The prospect of integrating succinic acid production in future biorefineries is assessed.

• 出版日期2016-8-15