Multiple roles of nicotine on cell proliferation and inhibition of apoptosis: Implications on lung carcinogenesis

作者：Catassi A; Servent D; Paleari L; Cesario A; Russo P^*

来源：Mutation Research-Reviews in Mutation Research, 2008, 659(3): 221-231.

DOI：10.1016/j.mrrev.2008.04.002

• nicotine
• human cancerogenesis
• promotion
• lung cancer
• nicotinic receptor
• apoptosis
• cell proliferation

The genotoxic effects of tobacco carcinogens have long been recognized, the contribution of tobacco components to cancerogenesis by cell surface receptor signaling is relatively unexplored. Nicotine, the principal tobacco alkaloid, acts through nicotinic acetylcholine receptor (nAChR). nAChR are functionally present on human lung airway epithelial cells, on lung carcinoma [SCLC and NSCLC] and on mesothelioma and build a part of an autocrine-prolifierative network that facilitates the growth of neoplastic cells. Different nAChR subunit gene expression patterns are expressed between NSCLC from smokers and non-smokers. Although there is no evidence that nicotine itself could induce cancer, different studies established that nicotine promotes in vivo the growth of cancer cells and the proliferation of endothelial cells suggesting that nicotine might contribute to the progression of tumors already initiated. These observations led to the hypothesis that nicotine might be playing a direct role in the promotion and progression of human lung cancers.

• 出版日期2008-10
• 单位中国地震局