A new era of semiconductor genetics using ion-sensitive field-effect transistors: the gene-sensitive integrated cell

作者：Toumazou Christofer^*; Thay Tan Sri Lim Kok; Georgiou Pantelis

来源：Philosophical Transactions of the Royal Society A-Mathematical Physical and Engineering Sciences, 2014, 372(2012): 20130112.

DOI：10.1098/rsta.2013.0112

• ion-sensitive field-effect transistor
• DNA
• genetics
• complementary metal-oxide semiconductor
• ISFET

Semiconductor genetics is now disrupting the field of healthcare owing to the rapid parallelization and scaling of DNA sensing using ion-sensitive field-effect transistors (ISFETs) fabricated using commercial complementary metal -oxide semiconductor technology. The enabling concept of DNA reaction monitoring introduced by Toumazou has made this a reality and we are now seeing relentless scaling with Moore's law ultimately achieving the $100 genome. In this paper, we present the next evolution of this technology through the creation of the gene-sensitive integrated cell (GSIC) for label-free real-time analysis based on ISFETs. This device is derived from the traditional metal-oxide semiconductor field-effect transistor (MOSFET) and has electrical performance identical to that of a MOSFET in a standard semiconductor process, yet is capable of incorporating DNA reaction chemistries for applications in single nucleotide polymorphism microarrays and DNA sequencing. Just as application-specific integrated circuits, which are developed in much the same way, have shaped our consumer electronics industry and modern communications and memory technology, so, too, do GSICs based on a single underlying technology principle have the capacity to transform the life science and healthcare industries.

• 出版日期2014-3-28