Azidation of anomeric nitro sugars: application in the synthesis of spiroaminals as glycosidase inhibitors

作者：Pal A P John; Vankar Yashwant D^*

来源：Tetrahedron Letters, 2010, 51(18): 2519-2524.

DOI：10.1016/j.tetlet.2010.03.003

• Nitro sugars
• Hydrolysis
• Azidation
• Spiroaminals
• Glycosidase inhibitors

6,5-Fused sugar-derived spiroaminals have been synthesized from the azido esters obtained via the nucleophilic substitution reactions of unstable Michael adducts derived from 1-nitro sugars. Most of the spiroaminals synthesized showed moderate but selective inhibitory activities toward some glycosidases.

• 出版日期2010-5-5