A novel and efficient synthesis of 2-substituted quinazolin-4(3H)-ones by the reaction of (het)arylmethanamines with isatoic anhydride

作者：Mandavi Mohammad; Hassanzadeh Rasool; Soheilizad Mehdi; Golshani Shiva; Moghimi Setareh; Firoozpour Loghman; Shafiee Abbas; Foroumadi Alireza

来源：Tetrahedron Letters, 2016, 57(33): 3770-3772.

DOI：10.1016/j.tetlet.2016.07.025

• Quinazoline
• One-pot
• Isatoic anhydride
• Aerobic conditions
• CuBr

A novel and straightforward method for the synthesis of quinazolin-4(3H)-ones is described. The one-pot reaction between isatoic anhydride and (het)arylmethanamines led to the formation of N-substituted anthranilamides, which under aerobic conditions in the presence of CuBr undergo an in situ oxidation-cyclization reaction to produce quinazolin-4(3H)-ones in good yields.

• 出版日期2016-8-17