An efficient and catalyst free methylthiolation of 4-(bromomethyl)-2H-chromen-2-ones with DMSO

作者：Chougala Bahubali M; Samundeeswari S; Holiyachi Megharaja; Naik Nirmala S; Shastri Lokesh A^*; Sunagar Vinay A

来源：Phosphorus, Sulfur, and Silicon and the Related Elements, 2017, 192(7): 874-879.

DOI：10.1080/10426507.2017.1290628

• 4-Bromomethyl-2H-chromen-2-one
• 4-[(methylthio)methyl]-2H-chromen-2-one
• DMSO
• methylthiolation

The first simple, metal free, and efficient protocol has been established for the methylthiolation of structurally diverse 4-bromomethyl-2H-chromen-2-ones using dimethyl sulfoxide (DMSO) as methylthiolation source at higher temperature. The experimental method is highly economical and provides excellent yields of highly pure products which do not require further purification. All novel 4-[(methylthio)methyl]-2H-chromen-2-ones were characterized by H-1, C-13 NMR, and single-crystal X-ray analysis.
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• 出版日期2017