A triantennary dendritic galactoside-capped nanohybrid with a ZnS/CdSe nanoparticle core as a hydrophilic, fluorescent, multivalent probe for metastatic lung cancer cells

作者：Chen Chien Tien^*; Munot Yogesh S; Salunke Santosh B; Wang Yi Ching; Lin Ruo Kai; Lin Chun Cheng; Chen Chia Chun; Liu Y Hsin

来源：Advanced Functional Materials, 2008, 18(4): 527-540.

DOI：10.1002/adfm.200700449

A new tri-antennary, galactoside-capped gallamide dendritic anchor with thiolate focal group is synthesized via click chemistry. The highly hydrophilic dendron was efficiently anchored onto the surface of CdSe/ZnS core/shell nanoparticles in a covalent fashion, as evidenced by H-1 NMR spectrum of the resultant nanohybrid with intact core fluorescent property. The water-soluble nano-hybrid was found smoothly and selectively uptaken by lung cancer cells enriched with membrane-bound asialoprotein receptors in 2-3 h, as evidenced by confocal microscopic analysis. Furthermore, cancer cells that are undergoing active mitosis also tend to uptake the nanohybrids efficiently and remain sustainable in serum-containing medium for several days, which shed light on its application as a photodynamic drug carrier for apoptosis study.

• 出版日期2008-2-22
• 单位清华大学