Application of SBA-15 mesoporous material as the carrier for drug formulation systems. Papaverine hydrochloride adsorption and release study

作者：Moritz Michal; Laniecki Marek^*

来源：Powder Technology, 2012, 230: 106-111.

DOI：10.1016/j.powtec.2012.06.061

• Mesoporous materials
• Phosphodiesterase inhibitor
• Drug delivery
• Drug reservoir
• Drug release kinetics

SBA-15 mesoporous material was used as a matrix in three different drug formulations (powders, granules and tablets). Hydroxypropyl cellulose (HPC) and stearic acid (SA) were applied as modifiers of papaverine hydrochloride release from mesoporous carriers. The samples were characterized by thermogravimetry, differential scanning calorimetry (DSc), X-ray diffraction (XRD) and nitrogen sorptometry at - 196 degrees C. High pressure applied during the drug formulation (granules, tablets) decreases both specific surface area and porosity of SBA-15. The changes in BET surface area were also observed after drug deposition. The Korsmeyer-Peppas model was applied to evaluate the kinetics of papaverine hydrochloride release from hydroxypropyl cellulose- and stearic acid-containing drug formulations. The extended drug release resulted from slow diffusion of the active substance from micro- and mesoporous channels blocked by hydrophobic stearic acid and organic polymer.

• 出版日期2012-11