Alkylation of Pyridines at Their 4-Positions with Styrenes plus Yttrium Reagent or Benzyl Grignard Reagents

作者：Mizumori Tomoya; Hata Takeshi; Urabe Hirokazu^*

来源：Chemistry - A European Journal, 2015, 21(1): 422-426.

DOI：10.1002/chem.201404635

• alkylation
• Grignard reagents
• pyridine
• regioselectivity
• yttrium

A new regioselective alkylation of pyridines at their 4-position was achieved with styrenes in the presence of yttrium trichloride, BuLi, and diisobutylaluminium hydride (DIBAL-H) in THF. Alternatively, similar products were more simply prepared from pyridines and benzyl Grignard reagents. These reactions are not only a useful preparation of 4-substituted pyridines but are also complementary to other relevant reactions usually giving 2-substituted pyridines.

• 出版日期2015-1-2