Association of IL-4 and IL-4 receptor gene polymorphisms with the risk, immunotherapeutic effects and prognosis of advanced renal cell carcinoma

作者：Fang, Xiaoxia; Zhu, Zhiling; Yang, Suyu; Ji, Yang; Wang, Lei^*

来源：International Journal of Clinical and Experimental Medicine, 2016, 9(6): 11449-11457.

• Interleukin-4
• Interleukin-4 receptor
• polymorphism
• renal cell carcinoma
• immunotherapy
• prognosis

We aimed to investigate the association of IL-4 and IL-4 receptor (IL-4R) gene polymorphisms with the immunotherapeutic effects and prognosis of advanced renal cell carcinoma (RCC) in Chinese population. Genotypes of rs2243250 and rs1805010 in IL-4 and IL-4R genes were detected in 112 advanced RCC patients and 150 healthy controls by PCR-RFLP, and these associations were analyzed by chi-square test and log-rank test. The distributions of genotype and allele of rs2243250 and rs1805010 in patients and controls were significant differences (P<0.05). But the clinical baselines, immunotherapeutic effects, and incidence of adverse events were not significant difference in patients with different genotype or allele (P>0.05). However, rs2243250 TT genotype carried patients had significantly longer median progression free survival (mPFS) and median overall survival (mOS) than others (Log rank P<0.05); rs1805010 carriers AG had significantly longer mPFS, AA had significantly longer mOS than others (Log rank P<0.05). Rs1805010 genotypes and adverse events of immunotherapy had prognosis value with a risk ratio of 1.86 and 1.65, respectively. We infer that the polymorphisms rs2243250 in IL-4 and rs1805010 in IL-4R gene could consider to be biomarkers of predicting the risk and survival for advanced RCC patients in Chinese population.

• 出版日期2016
• 单位新乡医学院