科研之友
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摘要
The design of a multinuclear low-field NMR unit with variable field strength < 6 mT providing accurate spin manipulations and sufficient sensitivity for direct detection of samples in thermal equilibrium to aid parahydrogen-based hyperpolarization experiments. An optimized, resistive magnet connected to a battery or wall-power driven current source was constructed to provide a magnetic field < 6 mT. A digital device connected to a saddle-shaped transmit- and solenoid receive-coil enabled MR signal excitation and detection with up to 10(6) samples/s, controlled by a flexible pulse-programming software. The magnetization of thermally polarized samples at 1.8 and 5.7 mT is detected in a single acquisition with a SNR a parts per thousand 10(1) and a parts per thousand 10(2) and a line width of 42 and 32 Hz, respectively. Nuclear spins are manipulated to an uncertainty of +/- 1A degrees by means of pulses, which can be arranged in an arbitrary combination. As a demonstration, standard experiments for the measurement of relaxation parameters of thermally polarized samples were implemented. The detection of much stronger hyperpolarized signal was exemplified employing parahydrogen. Direct detection of thermal and hyperpolarized H-1-MR signal in a single acquisition and accurate spin manipulations at 1.8 and 5.5 mT were successfully demonstrated.
- 出版日期2013-10
