Anti-Inflammatory Components of the Starfish Astropecten polyacanthus

作者：Nguyen Phuong Thao; Nguyen Xuan Cuong; Bui Thi Thuy Luyen; Tran Hong Quang; Tran Thi Hong Hanh; Kim Sohyun; Koh Young Sang; Nguyen Hoai Nam; Phan Van Kiem; Chau Van Minh; Kim Young Ho^*

来源：Marine Drugs, 2013, 11(8): 2917-2926.

DOI：10.3390/md11082917

• starfish
• Astropecten polyacanthus
• IL-12 p40
• IL-6
• TNF-alpha
• LPS-stimulated BMDCs

Inflammation is important in biomedical research, because it plays a key role in inflammatory diseases including rheumatoid arthritis and other forms of arthritis, diabetes, heart disease, irritable bowel syndrome, Alzheimer's disease, Parkinson's disease, allergies, asthma, and even cancer. In the present study, we describe the inhibitory effect of crude extracts and steroids isolated from the starfish Astropecten polyacanthus on pro-inflammatory cytokine (Interleukin-12 (IL-12) p40, interleukin-6 (IL-6), and tumor necrosis factor alpha (TNF-alpha)) production in lipopolysaccharide (LPS)-stimulated bone marrow-derived dendritic cells (BMDCs). Among those tested, compounds 5 and 7 showed potent inhibitory effects on the production of all three pro-inflammatory cytokines with IC50 values ranging from 1.82 +/- 0.11 to 7.00 +/- 0.16 mu M. Potent inhibitory activities were also observed for compound 1 on the production of IL-12 p40 and IL-6 with values of 3.96 +/- 0.12 and 4.07 +/- 0.13 mu M, respectively, and for compounds 3 and 4 on the production of IL-12 p40 with values of 6.55 +/- 0.18 and 5.06 +/- 0.16 mu M, respectively. Moreover, compounds 2 (IC50 = 34.86 +/- 0.31 mu M) and 6 (IC50 = 79.05 +/- 2.05 mu M) exhibited moderate inhibitory effects on the production of IL-12 p40, whereas compounds 3 (IC50 = 22.80 +/- 0.21 mu M) and 4 (IC50 = 16.73 +/- 0.25 mu M) moderately inhibited the production of TNF-alpha and IL-6, respectively.

• 出版日期2013-8
• 单位河北医科大学