科研之友
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摘要
Phragmitesaustralis (P australis), a world wide distributed wetland grass, is traditionally used as food making helper and spice in China. The pharmacological effect of this plant is poorly understood. Here, we demonstrated that lipopolysaccharide (LPS)-induced production of inflammatory mediators nitric oxide (NO) and reactive oxygen species (ROS), and the pro-inflammatory cytokines tumor necrosis factor-a (TNF-a) and interleukin-1 beta (IL-1 beta) in RAW264.7 macrophage were significantly inhibited by the crude extract. The inflammation pertinent signaling extra cellular signal-regulated kinase 1/2 (Erkl/2), P38MAPK, C-Jun and NF-kappaB (NF-kappa B) activated by LPS could be dramatically inhibited by this extract. It also remarkably inhibited bovine herpes virus type 1 (BoHV-1) replication in MDBK cells. Taken together, here, for the first time we provided P australisa a novel natural herb as a potential candidate for the generation of antiviral and anti-inflammatory agent.
