Melatonin sensitizes human malignant glioma cells against TRAIL-induced cell death

作者：Martin Vanesa^*; Garcia Santos Guillermo; Rodriguez Blanco Jezabel; Casado Zapico Sara; Sanchez Sanchez Ana; Antolin Isaac; Medina Maria; Rodriguez Carmen

来源：Cancer Letters, 2010, 287(2): 216-223.

DOI：10.1016/j.canlet.2009.06.016

• Melatonin
• Glioma
• TRAIL
• Apoptosis
• Death receptors

Despite the common expression of death receptors, many types of cancer including gliomas are resistant to the death receptor ligand (TRAIL). Melatonin antitumoral actions have been extensively described, including oncostatic properties on several tumor types and improvement of chemotherapeutic regimens. Here, we found that melatonin effectively increase cell sensitivity to TRAIL-induced cell apoptosis in A172 and U87 human glioma cells. The effect seems to be related to a modulation of PKC activity which in turns decreases Akt activation leading to an increase in death receptor 5 (DR5) levels and a decrease in the antiapoptotic proteins survivin and bcl-2 levels.

• 出版日期2010-1-28