Urotensin-II 143 G/A Polymorphism is not Associated with the Risk of Preeclampsia in Korean Women

作者：Na Sunghoon; Shim Jae Yoon^*; Jung Bok Kyung; Won Hye Sung; Lee Pil Ryang; Kim Ahm

来源：American Journal of Reproductive Immunology, 2011, 66(5): 423-427.

DOI：10.1111/j.1600-0897.2011.01022.x

• Polymorphism
• preeclampsia
• urotensin-II

Problem
Urotensin-II (UTS-II) may be associated with preeclampsia. We therefore assessed whether the UTS-II 143 G/A polymorphism is associated with preeclampsia in Korean women.
Method of study
This prospective case-control study enrolled 109 patients with preeclampsia and 144 healthy pregnant controls, all of whom were genotyped for the UTS-II 143 G/A polymorphism using the real-time TaqMan SNP Genotyping Assay.
Results
There was no significant difference in the distribution of the 143 G/A polymorphism or the frequency of the 143 A allele between women with preeclampsia and controls. In a dominant model, carriers of the A allele were not significantly more prevalent in the preeclamptic (53.2%) than in the control (60.4%) group. In addition, subgroup analysis showed no significant difference in genotype distribution or allelic frequency of the 143 G/A polymorphism between women with mild or severe preeclampsia and controls.
Conclusion
In Korean women, the common UTS-II 143 G/A polymorphism is unlikely to have an association with the risk of preeclampsia.

• 出版日期2011-11