Macular Perfusion in Healthy Chinese: An Optical Coherence Tomography Angiogram Study

作者：Yu, Jian; Jiang, Chunhui^*; Wang, Xiaolei; Zhu, Li; Gu, Ruiping; Xu, Huan; Jia, Yali; Huang, David; Sun, Xinghuai

来源：Investigative Ophthalmology & Visual Science, 2015, 56(5): 3212-3217.

DOI：10.1167/iovs.14-16270

• optical coherence tomography (OCT) angiogram
• split-spectrum amplitude-decorrelation angiography (SSADA) algorithm
• macular perfusion
• capillary-free zone

PURPOSE. To investigate macular perfusion in healthy Chinese individuals and examine its dependence on age and sex. @@@ METHODS. Healthy adult Chinese individuals were recruited. Macular perfusion was measured by spectral-domain optical coherence tomography (OCT) using the split-spectrum amplitudedecorrelation angiography (SSADA) algorithm. The parafoveal flow index and vessel area density as well as the area of the foveal capillary-free zone (CFZ) were quantified. @@@ RESULTS. A total of 76 eyes in 45 subjects were included (20 males and 25 females, mean age 36 +/- 11 years). The mean parafoveal flow index was 0.099 +/- 0.013; the mean vessel area density was 0.891 +/- 0.073; and the mean CFZ area was 0.474 +/- 0.172 mm(2). All three parameters were significantly correlated with age (flow index: P = 0.00; vessel area density: P = 0.00; CFZ area: P = 0.02). The flow index and vessel area density decreased annually by 0.6% and 0.4%, respectively, and CFZ area increased by 1.48% annually. The CFZ area was larger in females than in males, while all three parameters seemed to change more rapidly with age in males than in females. @@@ CONCLUSIONS. In healthy Chinese eyes, macular perfusion decreased with increasing age, and decreased more rapidly in males than in females. The application of OCT angiograms may provide a useful approach for monitoring macular perfusion, although caution must be exercised with regard to age-and sex-related variations.

• 出版日期2015-5
• 单位复旦大学