Discovery of 7-Oxo-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridine Derivatives as Potent, Orally Available, and Brain-Penetrating Receptor Interacting Protein 1 (RIP1) Kinase Inhibitors: Analysis of Structure-Kinetic Relationships

Yoshikawa Masato; Saitoh Morihisa; Katoh Taisuke; Seki Tomohiro; Bigi Simone V; Shimizu Yuji; Ishii Tsuyoshi; Okai Takuro; Kuno Masako; Hattori Harumi; Watanabe Etsuro; Saikatendu Kumar S; Zou Hua; Nakakariya Masanori; Tatamiya Takayuki; Nakada Yoshihisa; Yogo Takatoshi

doi:10.1021/acs.jmedchem.7b01647

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Discovery of 7-Oxo-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridine Derivatives as Potent, Orally Available, and Brain-Penetrating Receptor Interacting Protein 1 (RIP1) Kinase Inhibitors: Analysis of Structure-Kinetic Relationships

作者：Yoshikawa Masato; Saitoh Morihisa; Katoh Taisuke; Seki Tomohiro; Bigi Simone V; Shimizu Yuji; Ishii Tsuyoshi; Okai Takuro; Kuno Masako; Hattori Harumi; Watanabe Etsuro; Saikatendu Kumar S; Zou Hua; Nakakariya Masanori; Tatamiya Takayuki; Nakada Yoshihisa; Yogo Takatoshi

来源：Journal of Medicinal Chemistry, 2018, 61(6): 2384-2409.

DOI：10.1021/acs.jmedchem.7b01647