Negative correlation between D-dimer and homocysteine levels during pregnancy and the postpartum period a prospective study

作者：Haliloglu Berna^*; Aksungar Fehime Benli; Celik Aygen; Ilter Erdin; Coksuer Hakan; Ozekici Umit

来源：European Journal of Obstetrics & Gynecology and Reproductive Biology, 2010, 153(1): 23-26.

DOI：10.1016/j.ejogrb.2010.06.018

• Homocysteine
• Pregnancy
• Haemostasis
• D dimer

Objective There have been conflicting data about the role of increased levels of homocysteine (Hcy) on haemostatic system We aim to investigate prospectively the relation between serum Hcy levels and changes in haemostatic system in pregnancy and postpartum period
Study design Sixty-eight healthy pregnant women were included in the study Blood samples were obtained in the 11th gestational week 25th gestational week 32nd gestational week and postpartum 4th week The haemoglobin levels white blood cell count (WBC) platelet count activated partial thromboplastin time (aPTI-) prothrombin time (PT) fibrinogen D-dimer Hcy vitamin B12 and folate levels were measured
Results Serum Hcy levels were negatively correlated with D-dimer levels (r = -0 57 p < 0 0001) The highest levels of D-dimer (1046 62 +/- 322 01 ng/ml) were achieved in the third trimester and the lowest levels of serum Hcy (4 45 +/- 123 mmol/1) were detected in the same trimester In postpartum fourth week D dimer levels were decreased to normal levels (238 27 +/- 198 59 ng/ml) while the serum Hcy levels were reached to the highest levels (7 99 +/- 1 36 mmol/1)
Conclusion The negative correlation between Hcy and D-dimer levels may be a compensatory mechanism

• 出版日期2010-11