Association between osteoarthritis and mortality: a meta-analysis

作者：Han, Xiangzhen; Liu, Zhao; Kong, Lingde; Wang, Linfeng^*; Shen, Yong^*

来源：International Journal of Clinical and Experimental Medicine, 2017, 10(1): 1094-1100.

• Osteoarthritis
• mortality
• cardiovascular
• systematic review
• meta-analysis

Current evidence finds that the role of osteoarthritis (OA) on mortality remains controversial. Therefore, we conducted a meta-analysis to determine whether the association between OA and all-cause mortality as well as cardiovascular disease (CVD) related mortality exists. We searched the Pubmed, Embase and Cochrane Library databases, and identify cohort studies to evaluate the association between OA and mortality. Pooled risk ratios (RRs) with 95% confidence intervals (CIs) were calculated using random effects model. Subgroup analyses were performed to investigate potential sources of heterogeneity, and Stata 11.0 was used to analyze data. A total of 12 articles, involving 13 studies, were included in this meta-analysis. We did not find a statistically significant association between OA and all-cause mortality (RR = 1.06; 95% CI 0.89 to 1.28), and there was evidence of high heterogeneity of RRs across these studies (I-2 = 94.4%, P<0.001). However, when the studies were stratified by definition of mortality, a significant association was shown between OA and CVD mortality (RR = 1.36; 95% CI 1.10 to 1.69) with decreased heterogeneity (I-2 = 70.2%, P = 0.01). People with OA showed an increased risk of CVD related mortality although the association with overall mortality was less clear. However, additional high quality research is still required to further explore the relationship between OA and all-cause as well as specific-cause mortality.

• 出版日期2017
• 单位河北医科大学