AlCl3 catalyzed oxa-Diels-Alder reaction of aromatic aldehydes with simple dienes

作者：Jian, Wujun; Qian, Bo; Bao, Hongli^*; Li, Daliang^*

来源：Tetrahedron, 2017, 73(29): 4039-4044.

DOI：10.1016/j.tet.2016.10.049

• Oxa-Diels-Alder Reaction
• Aluminum chloride
• Aldehyde
• Simple diene

A highly regioselective and diastereoselective oxa-Diels-Alder reaction catalyzed by AlCl3 has been developed. This reaction is efficient and characterized by good functional group compatibility, F, Cl, CN, NO2, OMe and thiophenyl groups are tolerated. A Lewis acid catalyzed concerted cycloaddition mechanism is proposed based on the results.

• 出版日期2017-7-20
• 单位福建师范大学; 中国科学院福建物质结构研究所