A Facile Route to Boronic Acid Functional Polymeric Microspheres via Epoxide Ring Opening

作者：Vogt Andrew P; Trouillet Vanessa; Greiner Alexandra M; Kaupp Michael; Geckle Udo; Barner Leonie; Hofe Thorsten; Barner Kowollik Christopher^*

来源：Macromolecular Rapid Communications, 2012, 33(13): 1108-1113.

DOI：10.1002/marc.201200144

• boronic acid
• epoxide ring opening
• glucose FITC
• porous polymer microspheres
• surface modification

Boronic acid-functionalized microspheres are prepared for the first time via mild epoxide ring opening based on porous cross-linked polymeric microspheres (diameter similar to 10 mu m, porosity similar to 1000 angstrom). Quantitative chemical analysis by XPS and EA evidences that there is a greater functionalization with boronic acid when employing a sequential synthetic method [1.7 atom% boron (XPS); 1.12 wt% nitrogen (EA)] versus a one-pot synthetic method [0.2 atom% boron (XPS); 0.60 wt% nitrogen (EA)] yielding grafting densities ranging from approximately 2.5 molecules of boronic acid per nm2 to 1 molecule of boronic acid per nm2, respectively. Furthermore, the boronic acid-functionalized microspheres are conjugated with a novel fluorescent glucose molecule demonstrating a homogeneous spatial distribution of boronic acid.

• 出版日期2012-7-13