Ultrasound-guided percutaneous microwave ablation for adenomyosis: efficacy of treatment and effect on ovarian function

作者：Yang Yu; Zhang Jing^*; Han Zhi-yu; Ma Xia; Hao Yan-li; Xu Chang-tao; Xu Rui-fang; Zhang Bing-song

来源：Scientific Reports, 2015, 5(1): 10034.

DOI：10.1038/srep10034

• ANTI-MULLERIAN HORMONE
• INHIBIN-B
• PROLACTIN
• ENDOMETRIOSIS
• DIAGNOSIS

A total of 142 premenopausal women with symptomatic adenomyosis underwent ultrasound (US)guided percutaneous microwave ablation (PMWA) at the Chinese PLA General Hospital. This study aimed to evaluate changes in serum pituitary, gonadal hormone and cancer antigen 125 (CA125) levels after US-guided PMWA. Therefore, estradiol (E-2), follicle-stimulating hormone (FSH), prolactin (PRL) and CA125 levels were evaluated before ablation and at 3, 6, 9 and 12 months after ablation. No significant differences were observed in the E-2 and FSH levels pre-ablation and during follow-up (E-2: p = 0.933, p = 0.987, p = 0.106, p = 0.936; FSH: p = 0.552, p = 0.295, p = 0.414, p = 0.760). The mean absolute values of serum CA125 and PRL were significantly decreased at 3, 6, 9 and 12 months after ablation (CA125: p < 0.001, p < 0.001, p < 0.001, p = 0.003; PRL: p < 0.001, p < 0.001, p < 0.001, p < 0.001). A significant correlation between changes in CA125 levels and uterine volume was found (p < 0.001). No evidence of a decline in ovarian function was observed after US-guided PMWA.

• 出版日期2015-5-5
• 单位中国人民解放军总医院; 首都医科大学