Proteinase Inhibitors in the Cerebrospinal Fluid in Neurological Diseases

作者：Brylev L V^*

来源：Neurochemical Journal, 2009, 3(3): 214-220.

DOI：10.1134/S1819712409030106

• proteinase inhibitors
• cerebrospinal fluid
• alpha 2-macroglobulin
• cystatin C
• cystatin B
• alpha 1-antichymotripsin
• alpha 1-antitripsin
• neuroserpin
• inhibitor of plasminogen activator
• tissue inhibitor of matrix metalloproteinases

This review is focused on the properties of the most-studied inhibitors of proteolytic enzymes that are found in human cerebrospinal fluid. The possible roles of specific proteinase inhibitors in the pathogenesis of neurological diseases are discussed. We also considered perspectives for the use of assessment of their levels for disease diagnosis and prognosis.

• 出版日期2009-9