Modeled structure of trypanothione reductase of Leishmania infantum

作者：Singh Bishal K; Sarkar Nandini; Jagannadham M V; Dubey Vikash K^*

来源：BMB Reports, 2008, 41(6): 444-447.

DOI：10.5483/bmbrep.2008.41.6.444

• drug design
• structure-function
• reductase activity
• homology Modeling

Trypanothione reductase is an important target enzyme for structure-based drug design against Leishmania. We used homology modeling to construct a three-dimensional structure of the trypanothione reductase (TR) of Leishmania infantum. The structure shows acceptable Ramachandran statistics and a remarkably different active site from glutathione reductase(GR). Thus, a specific inhibitor against TR can be designed without interfering with host (human) GR activity.

• 出版日期2008-6-30
• 单位河北医科大学