A Novel Sealant Gel and Hollow Soluble Stent for Nonsuture Anastomosis of the Carotid Artery

作者：Fan, Henghua^*; Liang, Xiangdang; Zhang, Boxun; Wu, Di; Wu, Ji; Sun, Geng

来源：Journal of Biomaterials and Tissue Engineering, 2015, 5(11): 881-885.

DOI：10.1166/jbt.2015.1391

• Microvascular Anastomosis
• Thrombosis
• Adhesive
• Sealant Gel
• Hollow Soluble Stent

Background: This study aimed to develop a novel sealant gel and intravascular hollow soluble stent for nonsuture anastomosis of the carotid artery. Methods: New Zealand white rabbits received carotid artery anastomosis using this sealant gel, adhesive (cyanoacrylate), and stent. The control groups received either suture anastomosis or adhesive anastomosis but without this sealant gel. Biomechanical properties were compared between the adhesive and suture anastomoses. Patency of the carotid artery was monitored using Doppler ultrasonography until postoperative 5 months. Results: The adhesive group had significantly shorter anastomosis time than the suture group (4.8 +/- 0.8 vs. 26.8 +/- 7.1 min; P < 0.01). The adhesive anastomoses had significantly higher maximum stretching force (1.066 +/- 0.193 vs. 0.586 +/- 0.098; P < 0.05) and burst pressure (46.2 +/- 7.95 vs. 28.56 +/- 2.108; P < 0.01) than the suture anastomoses. All the arteries anastomosed using only the adhesive but not the sealant gel developed thromboses within 1 week after the surgery. However, only 3 out of 10 animals receiving anastomosis using both the sealant gel and adhesive developed thromboses. Conclusions: This novel sealant gel and hollow soluble stent can effectively prevent the infiltration of adhesive, and thus significantly decrease the risk of thrombosis. The adhesive anastomosis has significantly better biomechanical properties than the suture anastomosis.

• 出版日期2015-11
• 单位中国人民解放军总医院