A 13-week subchronic toxicity study of dietary administered saponin-rich and isoflavones-containing soybean extract in F344 rats

作者：Cho Y M^*; Imai T; Ito Y; Takami S; Hasumura A; Yamazaki T; Hirose M; Nishikawa A

来源：Food and Chemical Toxicology, 2009, 47(8): 2150-2156.

DOI：10.1016/j.fct.2009.06.001

• Soybean extract
• F344 rats
• Subchronic toxicity

A subchronic toxicity study of soybean extract was performed in F344 rats with dietary administration at concentrations of 0%, 1.25%, 2.5% and 5% for 13 weeks. No mortality or abnormal clinical signs in any group were observed. Body weight gains were decreased with a tendency for reduction of feed intake in the 1.25% and above female and 5% male groups. In males, absolute and relative liver weights were increased in the 1.25% and above groups. In females relative kidney weights were increased in the 1.25% and above groups. Other significant changes such as decreased RBC and hematocrit and increased urea nitrogen were detected in the 2.5% and/or 5% groups. On histopathological observation, atrophy of the ventral prostate was observed in all animals in the 5% male group. Mucification and atrophy of the vaginal epithelium and increased atretic follicles in ovaries were noted in 2.5% and 5% female rats. Based on the above findings the lowest-observed-adverse-effect level for male and female rats was estimated to be 1.25% (707.2 and 751.8 mg/kg b.w./day, respectively).

• 出版日期2009-8