Nanoparticle self-assembly directed by antagonistic kinase and phosphatase activities

作者：von Maltzahn Geoffrey; Min Dal Hee; Zhang Yingxin; Park Ji Ho; Harris Todd J; Sailor Michael; Bhatia Sangeeta N^*

来源：Advanced Materials, 2007, 19(21): 3579-+.

DOI：10.1002/adma.200701183

Superparamagnetic Fe3O4 nanoparticles (NPs) are engineered to reversibly self-assemble in response to antagonistic enzyme inputs. Tyrosine kinase activity directs substrate-NPs and SH2 domain-NPs to coalesce via polyvalent SH2- phosphopeptide binding. Phosphatase antagonizes this process and directs NP dispersion. By coupling assembly to substrate phosphorylation, the kinase activity is imaged via quantitative T2 relaxation changes in MRI.

• 出版日期2007-11-5