Blood viscosity and hemodynamics during exercise

作者：Connes Philippe^*; Pichon Aurelien; Hardy Dessources Marie Dominique; Waltz Xavier; Lamarre Yann; Simmonds Michael J; Tripette Julien

来源：Clinical Hemorheology and Microcirculation, 2012, 51(2): 101-109.

DOI：10.3233/CH-2011-1515

• Exercise
• hemorheology
• vasodilation
• vascular resistance
• nitric oxide

We tested the effects of submaximal exercise on blood viscosity (eta(b)), nitric oxide production (NO) and hemodynamics. Relationships between the exercise-induced changes that occurred in these parameters were investigated. Nine subjects performed exercise for 15 min at 105% of the first ventilatory threshold. Mean arterial pressure (MAP) and cardiac output (Qc) were measured, allowing the determination of systemic vascular resistance (SVR). Blood was sampled at rest and at the end of exercise. The eta(b) was determined at high shear rate and was used to calculate systemic vascular hindrance (VH). NO production was estimated by measuring plasma concentrations of NO stable end products (NOx). Qc, MAP,eta(b) and NOx, increased with exercise, whereas SVR and VH decreased. The changes between rest and exercise were calculated and tested for correlations. We observed: 1) a positive correlation between the increase in eta(b) and the increase in NOx; 2) a negative correlation between the increase in NOx and the decrease in VH; 3) a negative correlation between the increase in eta(b) and the decrease in SVR. Although the increase in Qc and blood flow during exercise probably promoted NO production due to shear dependent stimulation of the endothelium, the present results also support that the rise in eta(b) during exercise may be necessary for NO production and adequate vasodilation.

• 出版日期2012