Association of the rs1801133 variant in the MTHFR gene and sporadic Parkinson's disease

作者：Garcia Silvia; Mauricio Coral Vazquez Ramon; Gallegos Arreola Martha P; Angel Montes Almanza Luis; Canto Patricia; Arturo Garcia Martinez Froylan; Chavira Hernandez Gerardo; Palma Flores Carlos; Davila Maldonado Luis; Cuevas Garcia Carlos F; Lopez Hernandez Luz Berenice

来源：Folia Neuropathologica, 2015, 53(1): 24-28.

DOI：10.5114/fn.2015.49971

• rs1801133
• MTHFR
• Parkinson's disease
• common variants
• C677T
• Mexico

The MTHFR gene has been reported as a susceptibility locus for sporadic Parkinson's disease (sPD). The functional variant rs1801133 has been linked to hyperhomocysteinemia and dopaminergic cell death. Among different populations, Mexican-Mestizos (most present-day Mexicans) have the highest frequency of this variant. Therefore, we sought to determine a possible association of rs1801133 with SPD. In total, 356 individuals were included: 140 patients with PD, diagnosed according to the Queen Square Brain Bank criteria, and 216 neurologically healthy controls. Genotyping was performed using TaqMan probes for rs1801133 and real-time PCR. Logistic regression analysis with adjustment for smoking and gender was used to test for an association between genotype and SPD. The CC genotype was associated with SPD; exp(beta) = 2.06; 95% CI: 1.101-3.873, p = 0.024. No association with age at onset, cognitive impairment or gender was found in our study group. Our data suggest an important role of MTHFR gene variants in SPD.

• 出版日期2015