Limbic encephalitis with positive anti-N-methyl-D-aspartate antibodies. Report of one case

作者：David Martinez B; Rodrigo Guerrero T; Marcela Grandjean B; Luis Cartier R

来源：Revista Medica de Chile, 2012, 140(9): 1170-1173.

DOI：10.4067/S0034-98872012000900010

• Limbic encephalitis
• Nervous system
• Paraneoplastic syndromes
• Receptors, N-methyl-D-aspartate

Limbic encephalitis is a subacute syndrome characterized by memory impairment, confusion, seizures, hypothalamic dysfunction and psychiatric symptoms. It has been associated to tumors located outside of the central nervous system. In 2007, anti-N-methyl-D-aspartate receptors (NMDAr) antibodies were found in serum and CSF of patients with this particular type of encephalitis. We report a 25-year-old female who, following upper respiratory tract symptoms, developed serious behavioral and consciousness impairment that progressed to coma. Cerebrospinal fluid (CSF) analysis showed a lymphocyte pleocytosis, the electroencephalogram was altered with a slow encephalopathic rhythm and a brain magnetic resonance imaging was normal. Infectious etiologies were ruled out. CSF and serum anti NMDA receptors antibodies were positive. (Rev Med Chile 2012; 140: 1170-1173).

• 出版日期2012-9