Antitrypanosomal alkaloids from Polyalthia suaveolens (Annonaceae): Their effects on three selected glycolytic enzymes of Trypanosoma brucei

作者：Ngantchou Igor^*; Nyasse Barthelemy; Denier Colette; Blonski Casimir; Hannaert Veronique; Schneider Bernd

来源：Bioorganic & Medicinal Chemistry Letters, 2010, 20(12): 3495-3498.

DOI：10.1016/j.bmcl.2010.04.145

• Annonaceae
• Polyalthia suaveolens
• Alkaloids
• Trypanosomatidae
• Glycolysis
• Inhibition

In continuation of our study on medicinal plants of Cameroon, stem barks of Polyalthia suaveolens were phytochemically studied. This investigation yielded a new indolosesquiterpene alkaloid, named polysin (1) and four hitherto known alkaloids (2-5). Polysin (1) appeared as a competitive reversible inhibitor (K(i) = 10 mu M) of phosphofructo kinase (PFK) of Trypanosoma brucei with respect to fructose-6-phosphate (K(i)/K(M) = 0.05) and could be used in the design of new trypanocidal drugs. The other isolated compounds (2-5) also exhibited interesting inhibitory effects on selected glycolytic enzymes (PFK, glyceraldehyde-3-phosphate dehydrogenase and aldolase).

• 出版日期2010-6-15