Association of DASH Diet With Cardiovascular Risk Factors in Youth With Diabetes Mellitus The SEARCH for Diabetes in Youth Study

作者：Liese Angela D^*; Bortsov Andrey; Guenther Anke L B; Dabelea Dana; Reynolds Kristi; Standiford Debra A; Liu Lenna; Williams Desmond E; Mayer Davis Elizabeth J; D'Agostino Ralph B Jr; Bell Ronny; Marcovina Santica

来源：Circulation, 2011, 123(13): 1410-1417.

DOI：10.1161/CIRCULATIONAHA.110.955922

• diabetes mellitus
• lipids
• lipoproteins
• nutrition
• youth

Background-We have shown that adherence to the Dietary Approaches to Stop Hypertension (DASH) diet is related to blood pressure in youth with type 1 and type 2 diabetes mellitus. We explored the impact of the DASH diet on other cardiovascular disease risk factors.
Methods and Results-Between 2001 and 2005, data on total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triglycerides, low-density lipoprotein particle density, apolipoprotein B, body mass index, waist circumference, and adipocytokines were ascertained in 2130 youth aged 10 to 22 years with physician-diagnosed diabetes mellitus. Dietary intake was assessed by food frequency questionnaire, categorized into the DASH food groups, and assigned an adherence score. Among youth with type 1 diabetes mellitus, higher adherence to the DASH diet was significantly and inversely associated with low-density lipoprotein/high-density lipoprotein ratio and A(1c) in multivariable-adjusted models. Youth in the highest adherence tertile had an estimated 0.07 lower low-density lipoprotein/high-density lipoprotein ratio and 0.2 lower A(1c) levels than those in the lowest tertile adjusted for confounders. No significant associations were observed with triglycerides, low-density lipoprotein particle density, adipocytokines, apolipoprotein B, body mass index Z score, or waist circumference. Among youth with type 2 diabetes mellitus, associations were observed with low-density lipoprotein particle density and body mass index Z score.
Conclusions-The DASH dietary pattern may be beneficial in the prevention and management of cardiovascular disease risk in youth with diabetes mellitus. (Circulation. 2011;123:1410-1417.)

• 出版日期2011-4-5