African Burkitt Lymphoma: Age-Specific Risk and Correlations with Malaria Biomarkers

作者：Emmanuel Benjamin; Kawira Esther; Ogwang Martin D; Wabinga Henry; Magatti Josiah; Nkrumah Francis; Neequaye Janet; Bhatia Kishor; Brubaker Glen; Biggar Robert J; Mbulaiteye Sam M^*

来源：The American Journal of Tropical Medicine and Hygiene, 2011, 84(3): 397-401.

DOI：10.4269/ajtmh.2011.10-0450

African Burkitt lymphoma is an aggressive B-cell, non-Hodgkin lymphoma linked to Plasmodium falciparum malaria. Malaria biomarkers related to onset of African Burkitt lymphoma are unknown. We correlated age-specific pat terns of 2,602 cases of African Burkitt lymphoma (60% male, mean +/- SD age = 7.1 +/- 2.9 years) from Uganda, Ghana, and Tanzania with malaria biomarkers published from these countries. Age-specific patterns of this disease and mean multiplicity of P. falciparum malaria parasites, defined as the average number of distinct genotypes per positive blood sample based on the merozoite surface protein-2 assessed by polymerase chain reaction, were correlated and both peaked between 5 and 9 years. This pattern, which was strong and consistent across regions, contrasted parasite prevalence, which peaked at 2 years and decreased slightly, and geometric mean parasite density, which peaked between 2 and 3 years and decreased sharply. Our findings suggest that concurrent infection with multiple malaria genotypes may be related to onset of African Burkitt lymphoma.

• 出版日期2011-3