An alternative DNA damage pathway to apoptosis in hematological cancers

作者：Luk John M^*; Guan Kun Liang

来源：Nature Medicine, 2014, 20(6): 587-588.

DOI：10.1038/nm.3593

Although hematological cancers are genomically unstable, the mechanisms by which they evade DNA damage-induced cell death are largely unknown. A current study has revealed that the Hippo signaling pathway transcriptional regulator YAP1 activates an ABL1/p73-mediated proapoptotic effect in response to DNA damage, suggesting that YAP1 has a tumor suppressor function and that the Hippo pathway is a potential therapeutic target in human cancers.

• 出版日期2014-6